Phio Pharmaceuticals Corp. (PHIO)
NASDAQ (CM) NASDAQ (CM) Primary 
XMUN Summary
Best Value Stocks to Buy for April 23rd
PHIO and TGS made it to the Zacks Rank #1 (Strong Buy) value stocks list on April 23, 2025.
PHIO Stock Soars as Safety Panel Clears Skin Cancer Drug for Next Dose
Phio Pharmaceuticals stock rallies as safety committee gives green light to advance skin cancer candidate to next dose concentration in phase I study.
Cancer-Focused Phio Pharmaceuticals Stock Gains 300% On Monday - Here's Why
On Monday, Phio Pharmaceuticals Corp. PHIO stock skyrocketed with a strong session volume of 201.04 million, compared to the average volume of 362.72k, according to data from Benzinga Pro.
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Phio Pharmaceuticals Corp. Profile
| Biotechnology Industry | Healthcare Sector | Robert J. Bitterman CEO | NASDAQ (CM) Exchange | 71880W303 CUSIP |
| US Country | 5 Employees | - Last Dividend | 5 Jul 2024 Last Split | 10 May 2012 IPO Date |
Overview
Phio Pharmaceuticals Corp. is a pioneering entity in the field of immuno-oncology therapeutics within the United States, focusing on the development of innovative treatments designed to enhance the immune system's ability to fight cancer. Initially known as RXi Pharmaceuticals Corporation, the company underwent a name change to Phio Pharmaceuticals Corp. in November 2018, marking a new chapter in its mission to advance cancer treatment options. Incorporated in 2011 and based out of Marlborough, Massachusetts, Phio Pharmaceuticals Corp. is at the forefront of leveraging genetic insights and cutting-edge technology to develop therapies that target and suppress the mechanisms cancer cells use to evade the immune system.
Products and Services
Phio Pharmaceuticals Corp.'s research and development efforts have yielded a promising portfolio of INTASYL compounds, each designed to silence genes that play critical roles in the suppression of the immune response to cancer. These compounds include:
- PH-762: This compound is aimed at reducing the expression of the Cell Death Protein 1 (PD-1). PD-1 is a protein that inhibits the ability of T cells, a crucial component of the immune system, to kill cancer cells. By targeting PD-1, PH-762 seeks to enhance the immune system's capacity to fight off cancer.
- PH-894: PH-894 focuses on silencing the BRD4 gene, a significant player in controlling gene expression within both T cells and tumor cells. By targeting BRD4, this compound not only affects the immune system's effectiveness but also directly impacts tumor growth and proliferation, making it a dual-action therapy with the potential to significantly disrupt cancer progression.
- PH-804: This compound targets TIGIT, a protein that inhibits the activity of Natural Killer (NK) cells, which are part of the body's first line of defense against cancer. By silencing TIGIT, PH-804 aims to unleash the full potential of NK cells against cancer cells, offering a promising strategy to boost the body's natural immune response to tumors.
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