Atyr Pharma Inc. (471A)
XDUS 
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ATyr Pharma, Inc. (ATYR) Announces Top Line Results For The Phase III EFZO-FIT Study Of Efzofitimod In Pulmonary Sarcoidosis (Transcript)
aTyr Pharma, Inc. (NASDAQ:ATYR ) Announces Top Line Results for the Phase III EFZO-FIT Study of Efzofitimod in Pulmonary Sarcoidosis September 15 2025 11:00 AM EDT Company Participants Ashlee Dunston - Director of Investor Relations & Corporate Communications Sanjay Shukla - President, CEO & Director Robert Bachman Jill Broadfoot - Chief Financial Officer Conference Call Participants Derek Archila - Wells Fargo Securities, LLC, Research Division Yasmeen Rahimi - Piper Sandler & Co., Research Division Faisal Khurshid - Leerink Partners LLC, Research Division Joseph Pantginis - H.C. Wainwright & Co, LLC, Research Division Prakhar Agrawal - Cantor Fitzgerald & Co., Research Division Jiale Song - Jefferies LLC, Research Division Brian Abrahams - RBC Capital Markets, Research Division Yale Jen - Laidlaw & Company (UK) Ltd.
aTyr Pharma: Good Safety Data In Pulmonary Sarcoidosis, Institutions Are Accumulating
aTyr Pharma's pivotal data readouts in 2025 for SSc-ILD (Phase 2) and pulmonary sarcoidosis (Phase 3) could significantly impact its market potential and approval prospects. Efzofitimod shows promise in reducing fibrosis without immunosuppression, with recent safety data and a peer-reviewed publication bolstering confidence in its efficacy. Institutional ownership has surged to nearly 80%, indicating strong institutional confidence despite the inherent risks associated with earlier trial failures.
aTyr Pharma, Inc. (ATYR) Q4 2024 Earnings Call Transcript
aTyr Pharma, Inc. (NASDAQ:ATYR ) Q4 2024 Earnings Conference Call March 13, 2025 5:00 PM ET Company Participants Ashlee Dunston - Senior Director of Investor Relations and Public Affairs Sanjay Shukla - President and Chief Executive Officer Leslie Nangle - Vice President of Research Jill Broadfoot - Chief Financial Officer Conference Call Participants Derek Archila - Wells Fargo & Company Yasmeen Rahimi - Piper Sandler Companies Faisal Khurshid - Leerink Partners LLC Prakhar Agrawal - Cantor Fitzgerald, L.P. Gregory Renza - RBC Capital Markets Joe Pantginis - H.C.
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Atyr Pharma Inc. Profile
| Biotechnology Industry | Healthcare Sector | Sanjay S. Shukla CEO | XDUS Exchange | US0021202025 ISIN |
| US Country | 56 Employees | - Last Dividend | - Last Split | - IPO Date |
Overview
aTyr Pharma, Inc. is a pioneering biotherapeutics company primarily engaged in the exploration and development of novel medicines targeting unique immunological pathways. With its foundation laid in 2005 and strategically headquartered in San Diego, California, aTyr Pharma is focused on the United States market, spearheading innovative solutions to address unmet medical needs in the domain of immune modulation. The company’s efforts center around harnessing the profound complexities of immunology to pioneer breakthrough treatments, positioning it at the forefront of addressing challenging diseases with significant impacts on patients' quality of life.
Products and Services
- efzofitimod (ATYR1923)
aTyr Pharma’s flagship therapeutic candidate, efzofitimod, epitomizes the company’s innovative approach. It is a selective modulator of Neuropilin-2 (NRP2), embodying a new class of therapeutics. Currently, efzofitimod is undergoing a Phase III clinical trial for pulmonary sarcoidosis, a condition that involves the growth of tiny inflammatory cells in various parts of the body, primarily the lungs. Additionally, it is in a Phase 1b/2a clinical trial for the treatment of other interstitial lung diseases (ILDs), including chronic hypersensitivity pneumonitis and connective tissue disease-related ILD, highlighting its potential as a versatile treatment option for multiple lung conditions.
- ATYR0101
Focused on tackling fibrotic diseases, ATYR0101 is a fusion protein based on a domain of aspartyl-tRNA synthetase. This novel compound is currently in the preclinical development stage and represents aTyr Pharma’s commitment to expanding its portfolio into treatments for fibrosis-affected organs and tissues. ATYR0101 reflects the company's expertise in protein-based therapeutics and its ability to exploit the therapeutic potential of tRNA synthetase domains.
- ATYR0750
Targeting liver disorders, ATYR0750 is another testament to aTyr Pharma’s innovative edge. This developmental candidate, derived from a domain of alanyl-tRNA synthetase, is aimed at treating various liver conditions. Currently in the research and development phase, ATYR0750 emphasizes the company’s dedication to leveraging its foundational science in tRNA synthetase biology to explore treatment options for a broader spectrum of diseases.
In addition to its product development efforts, aTyr Pharma has established a strategic collaboration and license agreement with Kyorin Pharmaceutical Co., Ltd., focusing on the development and commercialization of efzofitimod for interstitial lung diseases in Japan. This partnership not only extends the global reach of aTyr’s innovative treatments but also underscores the international potential and recognition of its therapeutic candidates.
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