Summary
Agios Awaits Pyrukynd Decision in Thalassemia as FDA Misses Due Date
AGIO faces uncertainty as the FDA misses its Dec. 7 deadline related to the sNDA for Pyrukynd in thalassemia and offers no new timeline.
AGIO Stock Hits 52-Week Low on Mixed Sickle Cell Disease Study Results
Agios slides to a 52-week low after mixed phase III RISE UP data show a hemoglobin boost but no significant cut in pain crises.
Agios Pharmaceuticals, Inc. (AGIO) Discusses Topline Results from RISE UP Phase 3 Trial of Mitapivat in Sickle Cell Disease Transcript
Agios Pharmaceuticals, Inc. ( AGIO ) Discusses Topline Results from RISE UP Phase 3 Trial of Mitapivat in Sickle Cell Disease November 19, 2025 8:00 AM EST Company Participants Morgan Sanford Brian Goff - CEO & Director Sarah Gheuens - Chief Medical Officer and Head of Research & Development Tsveta Milanova - Chief Commercial Officer Conference Call Participants Biree Andemariam Eric Schmidt - Cantor Fitzgerald & Co., Research Division Salveen Richter - Goldman Sachs Group, Inc., Research Division Ellen Horste - TD Cowen, Research Division Alec Stranahan - BofA Securities, Research Division Emily Bodnar - H.C. Wainwright & Co, LLC, Research Division Tessa Romero - JPMorgan Chase & Co, Research Division Luca Issi - RBC Capital Markets, Research Division Presentation Operator Good morning, and welcome to the Agios Pharmaceuticals Investor Conference Call and Webcast.
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Agios Pharmaceuticals Inc. Profile
| Biotechnology Industry | Healthcare Sector | Brian M. Goff CEO | NASDAQ (NGS) Exchange | 00847X104 CUSIP |
| US Country | 486 Employees | - Last Dividend | - Last Split | - IPO Date |
Overview
Agios Pharmaceuticals, Inc., established in 2007 and based in Cambridge, Massachusetts, is a pioneering biopharmaceutical company. It focuses on the discovery and development of novel medications targeting cellular metabolism for the treatment of various diseases in the United States. By leveraging its expertise in the field of cellular metabolism, Agios is dedicated to advancing a diverse pipeline of therapeutic candidates aimed at addressing unmet medical needs.
Products and Services
- PYRUKYND (mitapivat): An innovative activator of both wild-type and mutant forms of the pyruvate kinase (PK) enzyme. This flagship product by Agios Pharmaceuticals, Inc. is designed for the treatment of hemolytic anemias, a group of disorders characterized by the premature destruction of red blood cells, leading to a deficiency in healthy red blood cells in the body. Mitapivat has shown promise in addressing the underlying metabolic dysfunctions found in these conditions.
- AG-946: Another PK activator in the company’s robust pipeline, AG-946 is currently being developed as a potential therapeutic option for patients with lower-risk myelodysplastic syndrome (MDS) and hemolytic anemias. By targeting PK, this compound aims to correct metabolic irregularities that contribute to the pathology of these disorders, offering hope for improved treatments.
- AG-181: A phenylalanine hydroxylase stabilizer being explored for its potential in treating phenylketonuria (PKU). PKU is a metabolic disorder caused by a deficiency of the enzyme phenylalanine hydroxylase, leading to high levels of phenylalanine in the blood, which can result in a variety of health problems. AG-181 aims to stabilize the enzyme, thereby reducing phenylalanine levels and mitigating the symptoms associated with PKU.
- siRNA Therapy for Polycythemia Vera: In its preclinical development stage, Agios is also investigating a small interfering RNA (siRNA) therapy targeting polycythemia vera, a rare blood disorder characterized by an overproduction of red blood cells. This innovative approach aims to silence specific gene expressions, offering a novel therapeutic pathway for managing this condition.
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