Imugene Ltd. (IUGNF)
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Imugene hits 82% response rate in blood cancer trial - ICYMI
Imugene Ltd (ASX:IMU, OTC:IUGNF) earlier this week reported new clinical data from its Phase 1b trial evaluating azer-cel in patients with diffuse large B-cell lymphoma (DLBCL), including those who had previously failed CAR-T therapies. The company said the trial has achieved an 82% overall response rate in the CAR-T-fail population, with every patient experiencing either a complete response or partial response.
Imugene prepares pivotal azer-cel trial with FDA - ICYMI
Imugene Ltd (ASX:IMU, OTC:IUGNF) earlier this week provided an update on its cell therapy candidate azer-cel, highlighting strong response rates and upcoming regulatory and scientific milestones. The company said azer-cel achieved an 81% response rate in patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) who had previously failed autologous CAR-T therapy.
Imugene activates Australian site for Phase II bowel cancer vaccine trial
Imugene Ltd (ASX:IMU, OTC:IUGNF) has activated its first Australian site in the Phase II Neo-POLEM trial, expanding the clinical investigation of its PD1-Vaxx immunotherapy for a difficult-to-treat form of colorectal cancer. The investigator-sponsored study trial (IST) is now recruiting patients in both Australia and the United Kingdom to assess PD1-Vaxx – a neoadjuvant B-cell vaccine designed to trigger an immune response against PD-1 – in patients with mismatch repair-deficient or microsatellite instability-high (dMMR/MSI-high) colorectal cancer.
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Imugene Ltd. Profile
| - Industry | - Sector | James G. Silk CEO | OTC PINK Exchange | AU000000IMU9 ISIN |
| US Country | 80 Employees | - Last Dividend | 2 Jul 2025 Last Split | - IPO Date |
Overview
Imugene Limited is a pioneering clinical stage immuno-oncology company based in Sydney, Australia, established in 1986. The company focuses on developing a diverse array of immunotherapies designed to activate the immune system of cancer patients for the eradication of tumors. Imugene's commitment to innovation in cancer treatment is demonstrated through its collaboration with Arovella Therapeutics Ltd and a research partnership with RenovoRx, Inc. These collaborations aim to enhance the efficacy of treating and accessing difficult-to-treat tumors through advanced oncolytic virus therapy and integrated cell therapy platforms.
Products and Services
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HER-Vaxx:
A leading product of Imugene, HER-Vaxx, targets HER2-positive cancers, including gastric and breast cancers, by stimulating a polyclonal antibody response against HER2/neu receptors. Currently undergoing a phase 2 study for gastric cancer, HER-Vaxx represents a significant advancement in targeted cancer immunotherapy, offering hope for patients with these aggressive forms of cancer.
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PD1-Vaxx:
Another innovative product in Imugene's portfolio, the PD1-Vaxx vaccine, is designed to block PD-1 signalling, thereby inducing the body to produce polyclonal antibodies. This mechanism is crucial for enhancing the immune system's capability to fight cancer. PD1-Vaxx is currently in a phase I trial, showcasing Imugene's dedication to expanding its range of cancer immunotherapies.
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CF33:
Imugene is also developing CF33, a multifaceted oncolytic virus derived from various genomic sequences of vaccinia virus strains. This approach aims to generate a potent virus capable of effectively targeting and eliminating cancer cells. The innovative nature of CF33 highlights Imugene's commitment to exploring diverse therapeutic strategies to combat cancer.
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