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Ionis Pharmaceuticals, Inc. (IONS) Presents at Stifel 2025 Healthcare Conference Transcript
Ionis Pharmaceuticals, Inc. ( IONS ) Stifel 2025 Healthcare Conference November 13, 2025 8:00 AM EST Company Participants Kyle Jenne - Executive VP & Chief Global Product Strategy Officer Elizabeth L. Hougen - Executive VP of Finance & CFO Conference Call Participants Paul Matteis - Stifel, Nicolaus & Company, Incorporated, Research Division Presentation Paul Matteis Stifel, Nicolaus & Company, Incorporated, Research Division Good morning.
Ionis Pharmaceuticals, Inc. (IONS) Discusses Detailed Phase III Results for Olezarsen in Severe Hypertriglyceridemia Transcript
Ionis Pharmaceuticals, Inc. ( IONS ) Discusses Detailed Phase III Results for Olezarsen in Severe Hypertriglyceridemia November 8, 2025 3:00 PM EST Company Participants D. Walke - Senior Vice President of Investor Relations Brett Monia - Founder, CEO & Director Sotirios Tsimikas - Senior Vice President of Global Cardiovascular Development Kyle Jenne - Executive VP & Chief Global Product Strategy Officer Conference Call Participants Jay Olson - Oppenheimer & Co. Inc., Research Division Mani Foroohar - Leerink Partners LLC, Research Division Jessica Fye - JPMorgan Chase & Co, Research Division Debjit Chattopadhyay - Guggenheim Securities, LLC, Research Division Denis Reznik - Raymond James & Associates, Inc., Research Division Zaki Molvi - Jefferies LLC, Research Division Tommie Reerink - Goldman Sachs Group, Inc., Research Division Yanan Zhu - Wells Fargo Securities, LLC, Research Division Julian Pino - Stifel, Nicolaus & Company, Incorporated, Research Division Luca Issi - RBC Capital Markets, Research Division Myles Minter - William Blair & Company L.L.C.
Ionis: Near-Term Launches With Blockbuster Potential Boosts Upside Despite Stock Rally
Ionis Pharmaceuticals maintains a Buy rating as its transformation to a commercial company accelerates, driven by wholly-owned product launches and revenue growth. Q3 results highlight a revenue shift toward Ionis-owned drugs, with Tryngolza outperforming and Dawnzera launching as a differentiated HAE prophylactic. Olezarsen's strong Phase 3 data in sHTG positions IONS for a blockbuster opportunity, despite market competition and ongoing patent litigation with Arrowhead.
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Ionis Pharmaceuticals, Inc. Profile
| Biotechnology Industry | Healthcare Sector | Brett P. Monia CEO | XDUS Exchange | US4622221004 ISIN |
| US Country | 1,069 Employees | - Last Dividend | - Last Split | 17 May 1991 IPO Date |
Overview
Ionis Pharmaceuticals, Inc. is a biotechnology company focused on the discovery and development of RNA-targeted therapeutics. Based in Carlsbad, California, the company has pioneered advances in drug discovery, particularly in the development of antisense therapies that modulate gene expression. Ionis Pharmaceuticals targets a wide range of diseases with a significant unmet medical need, including neurological disorders, cardiovascular diseases, and various rare diseases. Since its incorporation in 1989, Ionis has formed strategic collaborations with numerous leading biopharmaceutical companies, including Biogen, AstraZeneca, Bayer AG, GlaxoSmithKline plc, and several others, to advance its mission of delivering groundbreaking therapies to patients worldwide.
Products and Services
- SPINRAZA: A groundbreaking therapy for spinal muscular atrophy (SMA) in both pediatric and adult patients. This product demonstrates Ionis’ commitment to addressing neurological disorders with advanced RNA-targeted treatments.
- TEGSEDI: An antisense injection designed for the treatment of polyneuropathy in adults caused by hereditary transthyretin amyloidosis. This product highlights Ionis’ innovative approach to treating rare diseases through genetic modulation.
- WAYLIVRA: An antisense medicine for patients with familial chylomicronemia syndrome (FCS) and familial partial lipodystrophy, showcasing Ionis’ capability in tackling lipid disorders.
- Eplontersen: Currently in phase 3 study, Eplontersen is being developed as a treatment for all types of ATTR (transthyretin amyloidosis) through monthly self-administered subcutaneous injections, reflecting Ionis’ progression in self-care therapeutic solutions.
- Olezarsen: In development for patients with FCS and severe hypertriglyceridemia (SHTG), Olezarsen represents Ionis’ ongoing efforts to combat severe lipid disorders.
- Donidalorsen: Aimed at patients with hereditary angioedema, this candidate signifies Ionis’ investment in developing treatments for rare hereditary disorders.
- ION363: Focused on treating patients with amyotrophic lateral sclerosis, ION363 underscores the company’s dedication to addressing debilitating neurological conditions.
- Tofersen: Aimed to inhibit the production of superoxide dismutase 1, a key factor in certain neurological diseases, demonstrating Ionis’ focus on molecular level interventions.
- Pelacarsen: Targeting established cardiovascular disease and elevated lipoprotein(a) levels, highlighting Ionis’ efforts towards cardiovascular health solutions.
- Bepirovirsen: In development to inhibit the production of viral proteins associated with hepatitis B, showcasing Ionis’ venture into antiviral therapies.
- Other notable developments include IONIS-FB-LRx, to inhibit complement factor B and address the alternative complement pathway, and ION224, aimed at reducing the production of diacylglycerol acyltransferase 2, further illustrating the breadth of Ionis’ therapeutic ambitions.
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