Cullinan Therapeutics, Inc. (CGEM)
NASDAQ (NGS) NASDAQ (NGS) Primary Summary
Cullinan Therapeutics: Thesis Strengthening For This T-Cell Engager Specialist
Cullinan Therapeutics is rated a Buy, driven by a robust T-cell engager pipeline, savvy management, and a strong $430M+ cash position. CLN-049 (FLT3xCD3) shows ~30% CR rates in AML, with broad applicability, favorable safety, and a clear accelerated approval path via single-arm study. A clear path to market for CLN-049 and regulatory precedent set by predecessors in AML increase the attractiveness of this setup, along with long-lived IP.
Cullinan Therapeutics, Inc. (CGEM) Presents at Citi's 2026 Virtual Oncology Leadership Summit Transcript
Cullinan Therapeutics, Inc. (CGEM) Presents at Citi's 2026 Virtual Oncology Leadership Summit Transcript
Cullinan Therapeutics: Cash-Rich Biotech With Multiple Value Drivers
Cullinan Therapeutics is a cash-rich clinical-stage biotech with great autoimmune and AML T-cell research, which has promising catalysts for 2026. CGEM also partnered for zipalertinib, which is nearing NDA completion in Q1 2026. I believe this program alone could quickly unlock considerable shareholder value. Additionally, CGEM's CLN-978 (CD19xCD3) will enter Phase 1 and is progressing well as a potential long-term core value driver post-zipalertinib.
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Cullinan Therapeutics, Inc. Profile
| Pharmaceuticals Industry | Healthcare Sector | Nadim Ahmed CEO | NASDAQ (NGS) Exchange | 230031106 CUSIP |
| US Country | 111 Employees | - Last Dividend | 31 Aug 2009 Last Split | - IPO Date |
Overview
Cullinan Therapeutics, Inc. is a leading biopharmaceutical company based in Cambridge, Massachusetts, dedicated to discovering and developing innovative oncology therapies aimed at improving the lives of cancer patients across the United States. Initially established in 2016 as Cullinan Oncology, Inc., the company underwent a name change to Cullinan Therapeutics, Inc. in April 2024, reflecting its broadened focus on a range of therapeutic solutions beyond oncology. Through its commitment to cutting-edge research and development, Cullinan Therapeutics has positioned itself at the forefront of the biopharmaceutical industry, leveraging strategic partnerships and advanced scientific methodologies to tackle some of the most challenging cancers.
Products and Services
- CLN-619: A monoclonal antibody currently undergoing Phase I clinical trial, CLN-619 is designed for the treatment of solid tumors. This lead program exemplifies Cullinan Therapeutics’ commitment to advancing cancer care through innovative therapeutic solutions.
- CLN-049: A humanized bispecific antibody in Phase I clinical trials, CLN-049 aims to treat acute myeloid leukemia or myelodysplastic syndrome. This product represents the company’s endeavor to address hematologic malignancies with targeted therapies.
- CLN-418: In Phase 1 clinical trial, CLN-418 is a human bispecific immune activator targeted at treating multiple solid tumors. Developed in collaboration with Harbour BioMed US Inc., this therapy showcases Cullinan Therapeutics' focus on harnessing the body’s immune response to combat cancer.
- Zipalertinib: A bioavailable small molecule for patients with non-small cell lung cancer, Zipalertinib is being developed under a co-development agreement with Taiho Pharmaceutical Co., Ltd. It highlights Cullinan Therapeutics’ efforts in targeting specific cancer mutations.
- CLN-617: A fusion protein in development for the treatment of solid tumors, CLN-617 demonstrates the company’s ongoing investment in alternative therapeutic modalities to expand its oncology portfolio.
- CLN-978: Targeting relapsed/refractory B-cell non-Hodgkin lymphoma, CLN-978 is a T cell engaging antibody. This development product further signifies Cullinan Therapeutics’ commitment to exploring novel approaches in cancer immunotherapy.
In addition, Cullinan Therapeutics has forged crucial strategic alliances, including a license and collaboration agreement with Adimab, LLC for antibody discovery and/or optimization. These partnerships enable the enhancement of its R&D capabilities and ensure the development of forward-thinking cancer therapies.
