Olema Pharmaceuticals Inc. (OLMA)

Overview

Olema Pharmaceuticals, Inc. is a forward-thinking clinical-stage biopharmaceutical company that has dedicated its research and development efforts toward creating innovative therapies specifically designed for women’s cancers. Established initially as CombiThera, Inc., the company underwent a name change to Olema Pharmaceuticals, Inc. in March 2009, signaling a renewed focus and commitment to its mission. Olema Pharmaceuticals is based in San Francisco, California, and has been advancing cancer treatment options since its inception in 2006. The company’s strategic approach to combating women’s cancers through groundbreaking therapies showcases its commitment to addressing the needs of patients battling these diseases.

Products and Services

• OP-1250

OP-1250 represents the forefront of Olema Pharmaceuticals’ innovative product lineup, functioning as both an estrogen receptor (ER) antagonist and a selective ER degrader. This cutting-edge compound is currently undergoing a Phase 3 clinical trial aimed at treating recurrent, locally advanced, or metastatic estrogen receptor-positive, human epidermal growth factor receptor 2-negative breast cancer. The development of OP-1250 is significant due to its potential to offer a more effective treatment option for patients with this type of breast cancer, addressing a major unmet medical need.

• Combination Therapy with CDK4/6 Inhibitors

Expanding on the potential of OP-1250, Olema Pharmaceuticals is exploring its combination with CDK4/6 inhibitors such as palbociclib, ribociclib, and alpelisib. This innovative approach is currently in Phase 1/2 clinical trials, focusing on the treatment of recurrent, locally advanced, or metastatic estrogen receptor-positive human epidermal growth factor receptor 2-negative breast cancer. By leveraging the synergy between OP-1250 and CDK4/6 inhibitors, the company aims to enhance the efficacy of treatment and provide new hope to patients affected by this challenging condition.

• OPERA-01

With OPERA-01, Olema Pharmaceuticals further extends its commitment to addressing women’s cancers, targeting ER+/HER2- advanced or metastatic breast cancer. This developmental project signifies the company’s ongoing efforts to broaden its portfolio and bring forth new, effective treatments in the fight against breast cancer, emphasizing a patient-centric approach in oncology.