Coherus Biosciences Inc. (8C5)

Overview

Coherus BioSciences, Inc. is a biopharmaceutical entity focused on the inception, development, and commercialization of innovative cancer therapies, primarily servicing the United States. Initially founded as BioGenerics, Inc., the company underwent a rebranding in April 2012, adopting its current name, and is headquartered in Redwood City, California. Since its incorporation in 2010, Coherus BioSciences has established itself as a pivotal player in the biopharmaceutical field through its diverse product pipeline and strategic partnerships. It has engaged in multiple collaboration and licensing agreements, including with Junshi Biosciences for toripalimab, as well as Surface, Adimab LLC, Bioeq AG, Genentech, Inc., Vaccinex, Inc., Novartis Institutes for Biomedical Research, Inc., and GlaxoSmithKline Intellectual Property No. 4 Limited, thereby bolstering its research, development, and commercialization capabilities.

Products and Services

• UDENYCA: A biosimilar to Neulasta, UDENYCA aids in managing neutropenia, a common side effect of cancer treatment characterized by a decreased number of white blood cells. It is a long-acting granulocyte-colony stimulating factor that helps in reducing the duration of neutropenia.
• LOQTORZI: This novel PD-1 inhibitor represents a class of drugs designed to block the PD-1 receptor, a protein that prevents the immune system from attacking cancer cells. LOQTORZI is engineered for the treatment of various cancers by enhancing the body's immune response against tumor cells.
• Casdozokitug: An investigational recombinant human IgG1 monoclonal antibody targeting interleukin 27. It's being developed for its potential in cancer immunotherapy, focusing on the body's natural defense mechanisms to recognize and attack tumor cells.
• CHS-114: An investigational human afucosylated IgG1 monoclonal antibody with high specificity for CCR8. This antibody aims to target and diminish Treg cells in the tumor microenvironment, which are known to suppress the immune system's ability to fight cancer.
• CHS-1000: Targeting human ILT4, CHS-1000 is an antibody in development intended to modulate the tumor microenvironment from being cancer-favorable to one that supports immune system attack on cancer cells, thereby enhancing the efficacy of existing anti-PD-1 therapies.
• Immuno-Oncology Programs: Coherus BioSciences’ immuno-oncology portfolio includes NZV930, an antibody inhibiting CD73 to potentiate anti-tumor immunity, and GSK4381562, an antibody targeting CD112R for the treatment of solid tumors. These programs underscore the company’s dedication to developing novel interventions to enhance cancer patient outcomes.
• YUSIMRY: A biosimilar to Humira, YUSIMRY is designed for patients suffering from inflammatory diseases, such as rheumatoid arthritis and psoriasis, which are characterized by an overproduction of tumor necrosis factor (TNF) in the body. It offers a therapeutic alternative for managing these conditions.