Alnylam Pharmaceuticals Inc. (ALNY)
Summary
Alnylam Hit Hard As Investors Forced To Revise Future Profit Expectations
Alnylam Pharmaceuticals has declined nearly 40% from its all-time high, pressured by near-term TTR market dynamics and longer-term profitability concerns. The TTR business will likely remain "noisy" in the first half of 2026, but Amvuttra continues to gain share, and management guidance for 2026 was above expectations. Management alarmed the Street earlier this year with long-term spending guidance that was considerably higher than expected; management continues to prioritize R&D to realize the company's full long-term potential.
ALNY Q4 Earnings Beat, Sales Miss Despite Y/Y Growth, Stock Down
Alnylam tops Q4 earnings estimates but misses on sales despite 85% revenue growth, as booming Amvuttra demand fails to lift shares.
Alnylam Pharmaceuticals, Inc. (ALNY) Q4 2025 Earnings Call Transcript
Alnylam Pharmaceuticals, Inc. (ALNY) Q4 2025 Earnings Call Transcript
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Alnylam Pharmaceuticals Inc. Profile
| Biotechnology Industry | Healthcare Sector | Dr. Yvonne L. Greenstreet M.B.A., M.D. CEO | NASDAQ (NGS) Exchange | 02043Q107 CUSIP |
| United States Country | 2,500 Employees | - Last Dividend | - Last Split | 28 May 2004 IPO Date |
Overview
Alnylam Pharmaceuticals, Inc. is a leading biopharmaceutical company that specializes in discovering, developing, and commercializing innovative therapeutics based on ribonucleic acid interference (RNAi). Founded in 2002 and headquartered in Cambridge, Massachusetts, Alnylam is at the forefront of RNAi technology, employing this revolutionary science to tackle complex diseases at the genetic level. The company's commitment to innovation is underscored by its dynamic pipeline of products and its strategic collaborations with major players in the pharmaceutical industry, such as Regeneron Pharmaceuticals, Inc., Roche, Novartis AG, Vir Biotechnology, Inc., Dicerna Pharmaceuticals, Inc., Ionis Pharmaceuticals, Inc., and PeptiDream, Inc. These partnerships aim to expand the potential of RNAi therapy across various diseases, including those affecting the eye, central nervous system (CNS), and more.
Products and Services
- ONPATTRO (patisiran)
Approved for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis (hATTR) in adults, this product exemplifies Alnylam's commitment to addressing rare diseases with significant unmet needs.
- AMVUTTRA
Also targeting hATTR amyloidosis, AMVUTTRA is specifically approved for treating adults with polyneuropathy, showcasing the company's focused approach on this genetic disorder.
- GIVLAARI (givosiran)
For adults with acute hepatic porphyria (AHP), a rare metabolic disorder, GIVLAARI represents a significant advancement in treatment options, highlighting Alnylam's dedication to tackling challenging hepatic conditions.
- OXLUMO (lumasiran)
This product is designed for the treatment of primary hyperoxaluria type 1 (PH1), a rare genetic disorder, further demonstrating Alnylam's expertise in developing treatments for rare conditions.
- Development Pipeline
- Patisiran - in development for ATTR amyloidosis with cardiomyopathy.
- Cemdisiran - targeted to treat complement-mediated diseases.
- Belcesiran - for the treatment of alpha-1 liver disease.
- Elebsiran - aimed at chronic HBV infection treatment.
- Zilebesiran - under development to treat hypertension, in collaboration with Roche.
- ALN-APP - for Alzheimer's disease and cerebral amyloid angiopathy.
- ALN-HSD - targeted to treat NASH.
- Fitusiran - for the treatment of hemophilia, showcasing Alnylam's expansion into blood disorders.
- Inclisiran - aimed at treating hypercholesterolemia, highlighting Alnylam's foray into cardiovascular diseases.
- Vutrisiran - in phase 3 clinical trial for ATTR amyloidosis, underscoring ongoing commitment to this disease area.
