Alnylam Pharmaceuticals Inc (DUL)
Summary
DUL Chart
Alnylam Pharmaceuticals: More Than Meets The Eye After CARDIO-TTRansform
Alnylam Pharmaceuticals, Inc. shares have fallen 18% amid concerns over its ATTR-CM franchise following AstraZeneca/Ionis trial failure. I see pessimism as understandable but overdone; nucresiran's superior TTR knockdown and trial design differences support a credible case for TRITON-CM success. Even if TRITON-CM fails, Amvuttra's first-line share gains and Alnylam's diverse pipeline mitigate downside risk.
Alnylam Highlights AMVUTTRA Momentum, Resets 2026 TTR Revenue Outlook
Alnylam Pharmaceuticals NASDAQ: ALNY highlighted continued momentum for its AMVUTTRA treatment in transthyretin-mediated cardiomyopathy, while outlining a pipeline of upcoming clinical catalysts and discussing changes in the market that prompted a revision to its 2026 TTR franchise revenue outlook.
Alnylam's Zilebesiran Targets Twice-Yearly Blood Pressure Control in ZENITH Trial
Alnylam Pharmaceuticals NASDAQ: ALNY outlined its strategy for advancing zilebesiran, an investigational RNA interference, or RNAi, therapy designed to provide sustained blood-pressure control with twice-yearly dosing for people with uncontrolled hypertension and elevated cardiovascular risk.
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Alnylam Pharmaceuticals Inc Profile
| Biotechnology Industry | Healthcare Sector | Yvonne L. Greenstreet CEO | XHAN Exchange | US02043Q1076 ISIN |
| US Country | 2,500 Employees | - Last Dividend | - Last Split | 28 May 2004 IPO Date |
Overview
Alnylam Pharmaceuticals, Inc. is a leading biopharmaceutical company that specializes in discovering, developing, and commercializing innovative therapeutics based on ribonucleic acid interference (RNAi). Founded in 2002 and headquartered in Cambridge, Massachusetts, Alnylam is at the forefront of RNAi technology, employing this revolutionary science to tackle complex diseases at the genetic level. The company's commitment to innovation is underscored by its dynamic pipeline of products and its strategic collaborations with major players in the pharmaceutical industry, such as Regeneron Pharmaceuticals, Inc., Roche, Novartis AG, Vir Biotechnology, Inc., Dicerna Pharmaceuticals, Inc., Ionis Pharmaceuticals, Inc., and PeptiDream, Inc. These partnerships aim to expand the potential of RNAi therapy across various diseases, including those affecting the eye, central nervous system (CNS), and more.
Products and Services
- ONPATTRO (patisiran)
Approved for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis (hATTR) in adults, this product exemplifies Alnylam's commitment to addressing rare diseases with significant unmet needs.
- AMVUTTRA
Also targeting hATTR amyloidosis, AMVUTTRA is specifically approved for treating adults with polyneuropathy, showcasing the company's focused approach on this genetic disorder.
- GIVLAARI (givosiran)
For adults with acute hepatic porphyria (AHP), a rare metabolic disorder, GIVLAARI represents a significant advancement in treatment options, highlighting Alnylam's dedication to tackling challenging hepatic conditions.
- OXLUMO (lumasiran)
This product is designed for the treatment of primary hyperoxaluria type 1 (PH1), a rare genetic disorder, further demonstrating Alnylam's expertise in developing treatments for rare conditions.
- Development Pipeline
- Patisiran - in development for ATTR amyloidosis with cardiomyopathy.
- Cemdisiran - targeted to treat complement-mediated diseases.
- Belcesiran - for the treatment of alpha-1 liver disease.
- Elebsiran - aimed at chronic HBV infection treatment.
- Zilebesiran - under development to treat hypertension, in collaboration with Roche.
- ALN-APP - for Alzheimer's disease and cerebral amyloid angiopathy.
- ALN-HSD - targeted to treat NASH.
- Fitusiran - for the treatment of hemophilia, showcasing Alnylam's expansion into blood disorders.
- Inclisiran - aimed at treating hypercholesterolemia, highlighting Alnylam's foray into cardiovascular diseases.
- Vutrisiran - in phase 3 clinical trial for ATTR amyloidosis, underscoring ongoing commitment to this disease area.
Contact Information
