Hitachi Construction Machinery Co Ltd (HCM)
XHAN 
Summary
HCM Chart
HUTCHMED Lands GSK Deal Worth Up to $1.3B for KRAS-EGFR Cancer Therapy
HUTCHMED NASDAQ: HCM said it has entered a co-development and licensing agreement with GSK for ex-China rights to HMPL-A830, a preclinical KRAS-EGFR antibody-targeted therapy conjugate, or ATTC. The transaction has a total potential value of approximately $1.3 billion, including a $110 million upfront payment, according to Acting Chief Executive Officer and Chief Financial Officer Johnny Cheng.
HUTCHMED shares jump 17% on US$1.3 billion GSK cancer drug deal
Hutchmed (China) Ltd (AIM:HCM, NASDAQ:HCM, HKG:0013, FRA:H7T2) shares jumped 17% to 210p on Thursday after the oncology specialist struck a licensing agreement with GSK worth up to US$1.295 billion for its experimental KRAS-EGFR cancer therapy. The shares were up 30.5p from Wednesday's 179.5p close following news that GSK will receive exclusive rights outside Mainland China, Hong Kong, Macau and Taiwan to develop and commercialise HMPL-A830.
HUTCHMED (China) signs licensing deal with GSK for experimental solid tumour drug
GSK subsidiary GlaxoSmithKline Intellectual Property (No. 4) Ltd will pay a unit of HUTCHMED (China) $110 million upfront for rights to an experimental drug for solid tumours, the Chinese drugmaker said on Thursday.
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Hitachi Construction Machinery Co Ltd Profile
| Specialty Retail Industry | Consumer Discretionary Sector | Chig Fung Cheng CEO | XHAN Exchange | US44842L1035 ISIN |
| HK Country | 1,796 Employees | - Last Dividend | 30 May 2019 Last Split | - IPO Date |
Overview
HUTCHMED (China) Limited specializes in discovering, developing, and commercializing innovative treatments for cancer and immunological diseases, operating on a global scale with a significant presence in Hong Kong. Initially founded in 2000 as Hutchison China MediTech Limited, the company underwent a rebranding to HUTCHMED (China) Limited in May 2021, underscoring its evolution and growing ambitions in the healthcare sector. With its headquarters based in Central, Hong Kong, HUTCHMED has forged strategic collaborations with industry giants such as AstraZeneca, Lilly (Shanghai) Management Company, BeiGene, Innovent Biologics, and several others, facilitating the advancement of its robust pipeline geared towards addressing unmet medical needs in oncological and immunological disorders. Leveraging cutting-edge research and development capabilities, HUTCHMED aims to lead in the creation of targeted therapeutics and immunotherapies, positioning itself as a key player in the fight against some of the most challenging diseases.
Products and Services
- Savolitinib: An innovatively designed inhibitor targeting MET gene mutations, Savolitinib offers a new hope in the treatment of non-small cell lung cancer (NSCLC), various renal cancers, colorectal cancer (CRC), and gastric cancer (GC), providing patients with an option that specifically tackles the genetic basis of their condition.
- Fruquintinib: This highly selective inhibitor focuses on vascular endothelial growth factor receptors (VEGFR), crucial in tumor-induced angiogenesis. It's formulated for the management of CRC, breast cancer, GC, endometrial cancer (EMC), NSCLC, hepatocellular carcinoma, alongside various gastrointestinal and solid tumors, presenting a versatile option in anti-cancer care.
- Surufatinib: Targeting a broad spectrum of neuroendocrine tumors (NET), Surufatinib offers therapeutic possibilities for both pancreatic and non-pancreatic NET, biliary tract cancer, sarcoma, among others, by inhibiting angiogenesis and immune evasion pathways.
- Tazemetostat: An EZH2 inhibitor, Tazemetostat is employed in treating specific cases of epithelioid sarcoma and follicular lymphoma, exploiting epigenetic mechanisms to halt tumor growth.
- HMPL-523, HMPL-689, and Other Inhibitors: A diverse range of inhibitors like HMPL-523, targeting spleen tyrosine kinase, and HMPL-689, focusing on phosphoinositide 3'-kinase delta (PI3Kδ), among others, underscore HUTCHMED’s dedication to addressing various hematological cancers and chronic immune diseases with precision medicine.
- Collaborative Projects: In addition to its in-house developed therapies, HUTCHMED’s strategic alliances with pharmaceutical and biotech companies have enabled the development and commercialization of next-generation therapeutics, enhancing its portfolio and therapeutic impact.
