Ironwood Pharmaceuticals Inc. (I76)
XDUS 
Summary
Ironwood Pharmaceuticals: High Dependence On Its Next Trial
Ironwood Pharmaceuticals is a small-cap GI-focused biotech with strong LINZESS sales but looming patent expiry by 2029–2030. IRWD raised LINZESS full-year U.S. net sales guidance to $1.15–$1.2 billion and its own revenue forecast to $460–$485 million. Apraglutide, IRWD's pipeline asset for SBS-IF, showed statistically significant Phase 3 results and is key to future value.
Ironwood Q2 Earnings Beat Estimates, Revenues Lag, 2026 View Raised
IRWD tops Q2 earnings estimates, misses on revenues and lifts its 2026 outlook as strong Linzess demand drives year-over-year growth.
Ironwood Pharmaceuticals, Inc. (IRWD) Q2 2026 Earnings Call Transcript
Ironwood Pharmaceuticals, Inc. (IRWD) Q2 2026 Earnings Call Transcript
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Ironwood Pharmaceuticals Inc. Profile
| Specialty Retail Industry | Consumer Discretionary Sector | Thomas A. McCourt CEO | XDUS Exchange | US46333X1081 ISIN |
| US Country | 100 Employees | - Last Dividend | 2 Apr 2019 Last Split | 3 Feb 2010 IPO Date |
Overview
Ironwood Pharmaceuticals, Inc. is a forward-thinking healthcare company primarily engaged in the development and commercialization of gastrointestinal (GI) products. Originally known as Microbia, Inc., the company underwent a rebranding to Ironwood Pharmaceuticals, Inc. in April 2008. Since its incorporation in 1998, it has established its headquarters in Boston, Massachusetts, underlining its longstanding commitment to addressing complex GI disorders. Ironwood's strategic approach to healthcare solutions is reinforced through key partnerships with prominent industry players such as AbbVie Inc., AstraZeneca AB, and Astellas Pharma Inc. These collaborations are central to the development and international commercialization of its flagship product, linaclotide, alongside nurturing a pipeline of promising treatments aimed at a variety of GI and related conditions.
Products and Services
- Linaclotide (LINZESS/CONSTELLA): Marketed under the name LINZESS in the United States, Mexico, Japan, Saudi Arabia, and China, and as CONSTELLA in Canada and European countries, linaclotide is a first-in-class guanylate cyclase type-C (GC-C) agonist. This drug represents a cornerstone treatment developed by Ironwood Pharmaceuticals for adults suffering from irritable bowel syndrome with constipation (IBS-C) or chronic idiopathic constipation (CIC), providing significant relief and improving life quality for millions globally.
- IW-3300: Currently under development, IW-3300 is another GC-C agonist targeting the treatment of visceral pain conditions, which include interstitial cystitis/bladder pain syndrome and endometriosis. This innovative approach underscores Ironwood's ongoing commitment to expanding its portfolio to address unmet medical needs within the gastrointestinal and related pain markets.
- Apraglutide: A next-generation, long-acting synthetic peptide analog of glucagon-like peptide-2, Apraglutide is being explored as a potential treatment for rare GI-related diseases. This includes short bowel syndrome dependent on parenteral support and acute graft versus host disease, highlighting Ironwood's dedication to tackling less common but equally debilitating conditions.
- CNP-104: Ironwood Pharmaceuticals is also venturing into immune nanoparticle technology with CNP-104, aimed at treating primary biliary cholangitis. This innovative approach represents a broader initiative by the company to delve into novel therapeutic areas and technologies, potentially setting new standards in the healthcare industry.
