Supernus Pharmaceuticals Inc. (S49)

Overview

Supernus Pharmaceuticals, Inc. is a biopharmaceutical enterprise dedicated to addressing the complex challenges of central nervous system (CNS) diseases within the United States. Since its inception in 2005, based in Rockville, Maryland, Supernus has committed itself to the development and commercialization of innovative and effective treatments aimed at improving the quality of life for patients suffering from a broad range of CNS conditions. Its strategic approach involves a comprehensive research and development program, coupled with extensive clinical trials to ensure the efficacious and safe application of its products.

Products and Services

• Trokendi XR: An extended-release formulation of topiramate, designed to treat epilepsy and prevent migraine headaches by delivering a steady dosage of medication over an extended period.
• Oxtellar XR: An extended-release version of oxcarbazepine that serves as monotherapy for partial-onset seizures in both adults and children aged 6 to 17 years, streamlining the management of epilepsy with once-daily dosing.
• Qelbree: A novel, non-stimulant medication approved for the treatment of attention-deficit hyperactivity disorder (ADHD) in adults and pediatric patients aged 6 years and older, offering a new therapeutic option without the same abuse potential as traditional stimulant drugs.
• APOKYN: Provides acute, intermittent treatment of hypomobility or 'off' episodes in patients with advanced Parkinson's Disease (PD), contributing significantly to the management of mobility-related fluctuations experienced by these patients.
• XADAGO: A medication used alongside levodopa/carbidopa in PD patients experiencing 'off' episodes, enhancing the control of motor symptoms and improving patients' quality of life.
• MYOBLOC: A Type B toxin product indicated for the treatment of cervical dystonia and sialorrhea in adults, showcasing the importance of targeted therapy in managing complex motor disorders.
• GOCOVRI: Approved for treating dyskinesia in patients with PD, this medication contributes to the broader effort to manage the side effects associated with long-term PD treatment.
• Osmolex ER: This extended-release medication is designed for the treatment of Parkinson's disease and drug-induced extrapyramial reactions in adult patients, illustrating the ongoing need for innovative PD management strategies.
• In development, Supernus boasts a portfolio of promising candidates, including SPN-830, a late-stage drug/device combination for 'off' episodes in PD; and SPN-817, a novel, first-in-class selective acetylcholinesterase inhibitor in Phase II trials for epilepsy. Other candidates like SPN-820, targeting resistant depression, and SPN-443 as well as SPN-446 and SPN-448 in earlier stages for ADHD/CNS and narcolepsy treatment, respectively, illustrate the company’s dedication to expanding its array of CNS therapies.