Venture investor and healthcare operating executive with experience sourcing and scaling clinical-stage life-science companies, advising boards and structuring early-to-growth-stage financings. Megan J. Lottier brings cross-functional expertise in commercial strategy, regulatory pathway planning and fundraising support, often partnering with founders and later-stage sponsors to de-risk clinical programs and accelerate go-to-market execution in North America and Europe.
Venture investor and healthcare operating executive with experience sourcing and scaling clinical-stage life-science companies, advising boards and structuring early-to-growth-stage financings. Megan J. Lottier brings cross-functional expertise in commercial strategy, regulatory pathway planning and fundraising support, often partnering with founders and later-stage sponsors to de-risk clinical programs and accelerate go-to-market execution in North America and Europe.
Specializes in early-to-growth-stage life‑science investments, prioritizing clinical-stage biotech and healthtech where commercial and regulatory strategy materially de-risks programs. Employs a hands-on, partnership-driven approach—working with founders and sponsors to align clinical endpoints, regulatory pathways and go‑to-market plans—while structuring financings to extend runways and preserve optionality. Investment selection emphasizes differentiated science with clear clinical inflection points, predictable reimbursement pathways, and experienced management teams. Time horizon is patient capital through clinical milestones; risk management combines staged capital, board-level governance and selective follow‑on reserves to protect value and accelerate North American and European market entry.
Specializes in early-to-growth-stage life‑science investments, prioritizing clinical-stage biotech and healthtech where commercial and regulatory strategy materially de-risks programs. Employs a hands-on, partnership-driven approach—working with founders and sponsors to align clinical endpoints, regulatory pathways and go‑to-market plans—while structuring financings to extend runways and preserve optionality. Investment selection emphasizes differentiated science with clear clinical inflection points, predictable reimbursement pathways, and experienced management teams. Time horizon is patient capital through clinical milestones; risk management combines staged capital, board-level governance and selective follow‑on reserves to protect value and accelerate North American and European market entry.
| Trades 1286 | Longs Won 900/1286 69% | Profit Factor 39.21 |
| Profitability | Shorts Won 0/0 0% | Standard Deviation $2.62M |
| Average Win $495,359.04 | Best Trade (Aug 14) $83.05M | Sharpe Ratio -10.67 |
| Average Loss -$29,453.02 | Worst Trade (Aug 02) -$571,859.04 | Z-Score 13.96 (100%) |
| Commissions $0 | Avg. Trade Length 1y 7m 3w 6d | Expectancy $337,833.8 |
| Loss Size | 100% | 90% | 80% | 70% | 60% | 50% | 40% | 30% | 20% | 10% |
| Probability of Loss | <0.01% | <0.01% | <0.01% | <0.01% | <0.01% | <0.01% | <0.01% | <0.01% | <0.01% | <0.01% |
| Consecutive Losing Trades | 55,556 | 50,000 | 44,444 | 38,889 | 33,333 | 27,778 | 22,222 | 16,667 | 11,111 | 5,556 |
| Symbol | Quantity | Cost | Value | Comm. | Profit ($) | Gain (%) | Change |
|---|---|---|---|---|---|---|---|
AAUA Alpha Architect US Equity 3 ETF | 6,351 | $310,799.06 | $363,023.16 | - | $52,224.1 | 16.8% | +0.865% |
AVDE Avantis International Equity ETF | 3.17M | $196.27M | $288.76M | - | $92.49M | 47.13% | -0.458% |
AVDV Avantis International Small Cap Value ETF | 4,676 | $263,836.6 | $489,296.64 | - | $225,460.04 | 85.45% | -0.476% |
AVEM Avantis Emerging Markets Equity ETF | 627,972 | $38.8M | $56.21M | - | $17.41M | 44.88% | +0.101% |
AVRE Avantis Real Estate ETF | 34,924 | $1.55M | $1.7M | - | $153,991.79 | 9.96% | -0.754% |
AVUS Avantis U.S. Equity ETF | 605,983 | $49.76M | $77.32M | - | $27.56M | 55.38% | +0.567% |
AVUV Avantis U.S. Small Cap Value ETF | 17,148 | $1.23M | $2.15M | - | $922,667.18 | 75.28% | +0.032% |
BIV Vanguard Intermediate-Term Bond ETF (likely mapping for ticker 0V1L) | 6,757 | $520,336.96 | $510,423.78 | - | -$9,913.18 | -1.91% | -0.198% |
BRK-A Berkshire Hathaway Inc. | 2 | $1.6M | $1.53M | - | -$63,683.33 | -3.99% | +0.21% |
BSV Vanguard Short-Term Bond ETF | 17,960 | $1.41M | $1.39M | - | -$18,721.37 | -1.33% | -0.077% |
CECO CECO Environmental Corp. | 4,200 | $215,040 | $276,738 | - | $61,698 | 28.69% | +0.534% |
DCGO DocGo Inc. | 28,793 | $205,583 | $18,744.24 | - | -$186,838.76 | -90.88% | -2.399% |
DFAC Dimensional U.S. Core Equity 2 ETF | 12.34M | $372.27M | $548.95M | - | $176.68M | 47.46% | +0.361% |
DFAR Dimensional US Real Estate ETF | 153,284 | $3.39M | $4.11M | - | $714,806.57 | 21.08% | -0.52% |
DFAS Dimensional U.S. Small Cap ETF | 23,598 | $1.49M | $1.91M | - | $423,762.59 | 28.47% | -0.172% |
DFAT Dimensional US Targeted Value ETF | 36,207 | $1.92M | $2.56M | - | $644,686.83 | 33.64% | -0.155% |
DFAU Dimensional US Core Equity Market ETF | 13,131 | $436,606 | $679,923.18 | - | $243,317.18 | 55.73% | +0.544% |
DFAX Dimensional World ex U.S. Core Equity 2 ETF | 101,538 | $2.61M | $3.71M | - | $1.1M | 42.28% | -0.219% |
DFEM Dimensional Emerging Markets Core Equity 2 ETF | 2.16M | $60.2M | $81.32M | - | $21.12M | 35.08% | +0.426% |
DFEV Dimensional Emerging Markets Value ETF | 9,818 | $270,011.53 | $389,872.78 | - | $119,861.25 | 44.39% | +0.076% |