Kymera Therapeutics Inc. (KYMR)
NASDAQ (NMS) NASDAQ (NMS) Primary 
XKLS Summary
Kymera's CEO Sold $6 Million in Stock After a 170% Run
According to a Form 4, proceeds of approximately $6.0 million were realized from the exercise and immediate sale of 50,000 shares at $119.00 per share on July 7, 2026. The transaction reduced the insider's direct common stock holdings by 7%, leaving a residual direct position of 667,000 shares.
Kymera Therapeutics: Why It May Be Time To Jump On The Bandwagon (Upgrade)
Kymera Therapeutics (KYMR) is upgraded to Buy, driven by strong pipeline progress and a robust $1.5bn cash position. KT-621, an oral STAT6 degrader for atopic dermatitis, has accelerated Phase 2b timelines with topline data now expected by year-end 2026. KT-621's oral administration and promising early efficacy/safety data position KYMR to challenge injectable incumbents in a multi-billion dollar market.
Kymera: Building Toward A Defining 2H26 Moment
Kymera Therapeutics is rated Buy ahead of the 2H26 KT-621 Phase 2b readout, seen as a key inflection point. KT-621, a first-in-class oral STAT6 degrader, targets large, expanding markets in atopic dermatitis and other type 2 inflammatory diseases. Rapid trial enrollment, a strong balance sheet ($1.55B cash), and external validation position KYMR for potential high-value partnerships and lifecycle expansion.
Kymera Therapeutics Inc. Investors
| Name | Quantity | Cost | Value | Profit ($) | Gain (%) |
|---|---|---|---|---|---|
| CE Curtis Ellergodt Rothschild Investment LLC | 99 | $4,449.71 | $11,227.79 | $6,778.08 | 152.33% |
| SN Stephanie Nee HARBOR CAPITAL ADVISORS Inc. | 33,948 | $1.39M | $3.84M | $2.45M | 176.36% |
| BG Bart Gancher Intech Investment Management LLC | 13,673 | $717,373.33 | $1.54M | $825,933.73 | 115.13% |
 John H. Burbank III Passport Capital LLC | 8.66M | $354.03M | $977.17M | $623.13M | 176.01% |
 Yiheng Capital Management Yiheng Capital Management LP | 73,440 | $2.01M | $8.29M | $6.28M | 312.4% |
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Kymera Therapeutics Inc. Profile
| Biotechnology Industry | Healthcare Sector | Nello Mainolfi CEO | NASDAQ (NMS) Exchange | 501575104 CUSIP |
| US Country | 253 Employees | - Last Dividend | - Last Split | 21 Aug 2020 IPO Date |
Overview
Kymera Therapeutics, Inc. is a pioneering biopharmaceutical company committed to the discovery and development of innovative small molecule therapeutics that leverage the body’s natural protein degradation system to specifically target and eliminate disease-causing proteins. Established in 2015 and based in Watertown, Massachusetts, Kymera Therapeutics is at the forefront of harnessing proteolysis targeting chimeras (PROTACs) technology to address some of the most challenging diseases in immunology, oncology, and other fields.
Products and Services
- IRAK4 Program
This program is a testament to the company’s innovative approach, currently in Phase II clinical trial targeting a range of immunology-inflammation diseases such as hidradenitis suppurativa and atopic dermatitis. By focusing on the selective degradation of the IRAK4 protein, Kymera aims to offer novel treatments for conditions with significant unmet needs.
- STAT3 Program
Geared towards the treatment of hematologic malignancies, solid tumors, autoimmune diseases, and fibrosis, the STAT3 program represents Kymera Therapeutics' venture into oncology and autoimmune disorders. Leveraging the degradation of STAT3, this program seeks to provide effective therapies for diseases that are currently hard to treat.
- MDM2 Program
Another highlight in Kymera’s pipeline is the MDM2 program, dedicated to addressing both hematological malignancies and solid tumors. By exploiting the degradation pathway of the MDM2 protein, this program explores new horizons in cancer treatment, showcasing the flexibility and potential of PROTACs technology.
- STAT6
The STAT6 project focuses on tackling Type 2 inflammation present in allergic diseases. Through the selective degradation of the STAT6 protein, Kymera Therapeutics is venturing into the realm of allergy and immunology, aiming to develop therapies that can significantly improve patient outcomes in allergic conditions.
- TYK2
Addressing inflammatory bowel disease, psoriasis, psoriatic arthritis, and lupus, the TYK2 program underscores Kymera Therapeutics' commitment to inflammatory diseases. By targeting the TYK2 protein for degradation, the company is working on crafting innovative solutions that could transform the treatment landscape for patients suffering from these chronic conditions.
